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- First p articipants with obesity or o verweight w ith at least one w eight- r elated c omorbidity have been d osed in a U.S. 12-week Phase IIa study with once-monthly subcutaneous (SQ) depot formulation of s mall m olecule GLP-1 receptor a gonist ASC30. - Ultra-long-acting SQ depot formulation of small molecule ASC30 demonstrated a 36-day half-life in participants with obesity in the Phase Ib study, supporting once monthly administration.